W218 - Therapy of High Risk Pregnancy and Its Complications

Abstract Text: Problem: Dysregulated Complement Activation as a Common Pathway of Injury in complications of high risk pregnancy such as Pre eclampsia, miscarriage and anti phospholipid syndrome (Lynch A. M. and Salmon J.E. "Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications" in Placenta. 2010 July ; 31(7): 561–567).

Method: That appropriate complement inhibition is an absolute requirement for normal pregnancy. Defective placental development was associated with pregnancy loss and solely dependent on alternative pathway activation.

Results: Sulfonic nano polymers offer balanced modulation of dysfunction of alternate complement system.
Discussions: Nano formulation methods of sulfonic polymers with human safety record offer an extremely attractive therapeutic option to improve pregnancy outcome in high risk pregnancy and should be an integral part of therapy in pregnancy.