PRESIDENT ENDOCRINE TECHNOLOGY, LLC NY, New York, United States
Abstract Text: Problem: The current progress in The Cure of Type 1 Diabetes is limited due to the instant blood mediated inflammatory reaction (IBMIR) occurring in the liver hours and days after islet infusion. This is due to hyper activation of complement and coagulation pathway (Gamble A.C. Anissa et al: Review: REVIEW "The journey of islet cell transplantation and future development" ISLETS 2018, VOL. 10, NO. 2, 80–94 https://doi.org/10.1080/19382014.2018.1428511
Method: Early inhibition of Complement and coagulation pathway can be achieved safely by balanced inhibition of Factor D. This can be done by sulfonic nano polymers. Result: It is possible to improve islet cell transplantation results by including sulfonic polymers as inhibitor of complement and coagulation cascade along with islet cell infusion. This will allow improve islet cell tolerance, viability and functionality.
