Tu151 - Myeloid-derived Suppressor Cells Showed Differential Recruitment in SLE Animals Contributing to the Pathology

Valentina González – Universidad Andrés Bello; Valentina P Mora – Pontificia Universidad Católica de Chile; Alexis m Kalergis – Pontificia Universidad Católica de Chile; Jorge A Soto – Assistant Professor, Universidad Andrés Bello

Abstract Text: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect various organs. The overall incidence rates are between 1.5 to 11 cases per 100,000 people, with a higher predisposition in women than in men. Myeloid-derived suppressor cells (MDSC) are a cell type involved in multiple pathologies, such as cancer or infections, where they have been characterized by promoting a state that is detrimental to the host. In patients with SLE, increased arginase 1 (Arg1) secretion by MDSCs has been reported to contribute to pro-inflammatory responses. To evaluate the contribution of the MDSCs during the development and progression of systemic lupus erythematosus, two murine models capable of acute and chronic disease development were evaluated. In both models, we identified changes in the recruitment of granulocytic MDSC (G-MDSC) and monocytic MDSCs (M-MDSC) populations in the different target tissues. Also, these changes were accompanied by a specific cytokines pattern expression. In addition, MDSCs presented a possible APC phenotype, which could also be related to changes in different adaptive cells. This work presents new background on how MDSCs influence the progression of systemic lupus erythematosus.