Tu177 - Features of Humoral Immunity to sars-cov-2 in Kidney Transplant Recipients

Tamara Amvrosieva – Head of the Lab, Republican Scientific and Practical Center of Epidemiology and Microbiology, Minsk, Republic of Belarus; Inna Belskaya – Republican Scientific and Practical Center of Epidemiology and Microbiology, Minsk, Republic of Belarus; Zoya Bohush – Republican Scientific and Practical Center of Epidemiology and Microbiology, Minsk, Republic of Belarus; Kirill Komisarau – Head of Kidney Unit, Kidney Unit, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology,; Tatyana Chabatarova – nephlologist, Kidney Unit, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology,

Abstract Text: The objective of the study – to compare the features of post-infection and post-vaccination antibody response to SARS-CoV-2 in kidney transplant recipients and immunocompetent individuals.
The studies were carried out in recipients after COVID-19 (n=177) and recipients, immunized with Sputnik V (n=25) or Vero Cell (n=31) vaccines. COVID-19 immunocompetent convalescents (n=163) and persons, vaccinated with Sputnik V (n=257) or Vero Cell (n=160) were included.
SARS-CoV-2 post-infection seroprevalence among kidney transplant recipients was 86.4% to S protein and 59.9% to N protein after 21 days COVID-19 symptoms manifestation. The same parameter to S protein was 91.5% and 86.3% to N protein in the immunocompetent individuals (p < 0.001). IgG to the S protein of SARS-CoV-2 were detected in 70.3% of recipients and only 24.5% of patients were positive for IgG to the N protein after 1 year of onset of COVID-19 symptoms (in immunocompetent individuals – 80.3% to S protein and 46.5% to N protein (p < 0.001).
Seroprevalence in recipients with hybrid immunity after infection and vaccination with Sputnik V was 100%, after Vero Cell – 77.8%. High avidity IgG were observed in 33.3% of Sputnik V vaccinated recipients and were absent in Vero Cell vaccinated recipients (in immunocompetent individuals – 22.9% and 2.2%, respectively).
In kidney recipients indicators of post-infection and post-vaccination humoral immunity to SARS-CoV-2 were lower in comparison to immunocompetent persons. High avidity IgG detection level towards SARS-CoV-2 was notably higher in the group of individuals vaccinated with Sputnik V in comparison to individuals vaccinated with Vero Cell