Innovative Bioengineering Technologies and Strategies That Provide Mechanistic Insight and Guide Therapeutics in Cancer, Autoimmune Diseases and Transplant
Tuesday, June 20, 2023
1:30 PM – 5:30 PM
Location: Salon A-B
Organized By
Recent discoveries in bioengineering immunity have generated dramatic progress on multiple levels. As we begin to enhance our understanding of disease mechanisms in transplant rejection, autoimmune diseases and cancer, we undercover exciting opportunities to engineer new tools for biomedical discovery and treatment. This session will showcase novel bioengineering approaches and emerging areas such as most recent developments, design and application of next-generation nanotechnologies and bioengineering tools and the clinical advantages of using them within the fields of cancer immunotherapy, autoimmunity and transplantation.
During this session we will examine how to use engineering strategies and nanomaterials to induce anti-inflammatory processes or restore antigen-specific immunologic tolerance to autoantigens in autoimmune disease, induce tolerance to avoid transplant rejection and identify varied bioengineering approaches to inhibit tumor growth and modulate the tumor microenvironment to boost the antitumor immune response. Moreover, we will bring together investigators who will address key concepts identifying how to design these molecules to target critical pathological proceses.
Learning Objectives -To identify ways to manipulate inflammatory pathways for immunologic acceptance in transplant -To discuss strategies to leverage biomaterials to promote immune tolerance and limit autoimmune disease -To inform about promising advances in bioengineering strategies that offer better treatments for patients with a variety of diseases"
Organizing Societies American Society for Histocompatibility and Immunogenetics (ASHI) Association of Medical Laboratory Immunologists (AMLI)
Session Chairs Elaine Reed, PhD Barbara Detrick, PhD
Session Agenda 1:30 PM - 1:35 PM Introduction Barbara Detrick, PhD The Johns Hopkins University
1:35 PM - 2:15 PM Engineering CAR T-cells for Cancer Therapy: Exploring the Unique Role of IFN-gamma Signaling Marcela V. Maus, MD, PhD Harvard Medical School
2:15 PM - 2:55 PM Clinical Translation of Cardiac Xenografts: Overcoming Immunologic and Physiologic Barriers through Genetic Engineering Richard N Pierson III, MD Harvard Medical School
3:00 PM - 3:30 PM Break
3:30 PM - 4:10 PM Harnessing Bioengineering to Combat Autoimmunity with Next Generation Immunotherapies Christopher M Jewell, PhD University of Maryland
4:10 PM - 4:50 PM Delivery of Nanotherapeutics for Organ Transplantation Reza Abdi, MD Harvard Medical School
4:50 PM - 5:30 PM General Discussion and Concluding Remarks Annette Jackson Duke University