Engineered T-cell Therapies to Treat Autoimmune Diseases and Restore Immune Tolerance
Tuesday, June 20, 2023
1:30 PM – 4:30 PM
Location: Provincetown Room
Organized By
Engineered T-cell therapies targeting B cells have revolutionized the treatment of blood cancers and can be curative. Emerging data suggest that the unrivaled therapeutic potency of T-cell therapies, such as CD19-targeted chimeric antigen receptor (CAR)-T cells, can be leveraged to induce prolonged disease remission in patients with severe B cell-mediated autoimmune diseases, while regulatory T cells expressing CARs (CAR-Tregs) are advanced for both transplant tolerance and the treatment of autoimmunity. Beyond conventional CARs, novel T-cell engineering strategies provide unique opportunities to develop antigen-specific precision immunotherapies to selectively deplete autoreactive B cells or T cells, while preserving normal immune responses.
In this interdisciplinary symposium, we will highlight the extraordinary potential of engineered T-cell therapies as emerging treatments of organ-specific and systemic autoimmune diseases as well as transplant rejection. The symposium will juxtapose different engineering approaches that are being developed for antigen-specific targeting of autoreactive B cells (e.g., CAAR-T cells, CATCR-T cells), targeting of autoreactive T cells (e.g., pHLA-directed CAR-T cells), CAR-Treg therapies, and touch on the evolving clinical experience in using conventional CD19 CAR-T cells in severe autoimmune diseases. "
Organizing Societies American College of Rheumatology
Session Chairs Deepak Rao, MD, PhD Maximilian F. Konig, MD
Session Agenda 1:30 PM - 2:00 PM Targeted Cellular Immunotherapy with CAAR T cells for Patients with B cell-mediated Autoimmune Disease Silvio Manfredo Vieira, PhD University of Pennsylvania
2:00 PM - 2:30 PM Chimeric Autoantigen-T cell Receptor (CATCR)-T cell Therapy to Target Autoreactive B cells in Autoimmune Diseases Maximilian F. Konig, MD The Johns Hopkins University School of Medicine
2:30 PM - 3:00 PM Prevention and Treatment of Murine Models of Autoimmunity via Autoreactive T cell-specific CAR-T cells Chyi Hsieh, MD, PhD Washington University in St. Louis
3:00 PM - 3:30 PM Break
3:30 PM - 4:00 PM Inducing Antigen-specific Tolerance in Solid Organ Transplantation Anil K. Chandraker, MD Brigham and Women's Hospital
4:00 PM - 4:30 PM Allo- and Autoantigen-specific Tregs Megan Levings, PhD The University of British Columbia