Th175 - Third Generation Nonbiological covid-19 Vaccine

Abstract Text: The Problem: Omicron and its sub variants have exposed the weakness of first generation biological vaccines. SARS-CoV-2 have rapidly adapted to host immune system and first generation vaccines. This increases the future risk of periodic burst of Covid-19 Pandemics at global level.
Rationale: It is critical to target immune evasion, immune virulence and immune resistance part of immune pathogenesis of SARS-CoV2. The underlying molecular target is Factor H as shown in the development of biological meningococcal vaccine ( Lisa K. McNeil, et al "Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease Microbiol. Mol. Biol. Rev. 2013, 77(2):234. DOI: 10.1128/MMBR.00056-12. (We characterize as Second generation Biological Vaccines)

Method: We have developed nonbiological third generation vaccine targeting immune evasion, immune virulence, immune resistance and inflammation mechanism of Factor H involved in Covid-19 pandemics.
Discussions: Sulfonic nanopolymers as inhibitors of Factor H and Factor D can be rapidly adapted to assist and improve first generation biological vaccine in Covid-19 and enhance the prospect of herd immunity at a global levels.