PRESIDENT ENDOCRINE TECHNOLOGY, LLC NY, New York, United States
Abstract Text: The Problem: Novel therapies are urgently needed to combat the global threat of multi drug-resistant pathogens such as Neisseria gonorrhoeae.
Method: Neisseria gonorrhoeae, express glycans, including N-acetylneuraminic acid (Neu5Ac), that mimic host structures to evade host immunity. Neu5Ac is a negatively charged 9-cabon sugar that inhibits complement, in part by enhancing binding of the complement inhibitor factor H (FH) through C-terminal domains (19 and 20) on FH. (Ram S. et al. "Utilizing complement evasion strategies to design complement based antibacterial immunotherapeutics: lessons from the pathogenic Neisseriae" Immunobiology. 2016 October ; 221(10): 1110–1123. doi:10.1016/j.imbio.2016.05.016) Result: Sulfonic nano polymers by targeting complement evasion strategies of Factor H can be designed as complement based antibacterial for Multi Drug Resistant Neisseria gonorrhoeae as immunotherapeutics. Such strategy will have added advantage to target immune evasion, immune virulence, immune resistant and drug resistant microbes. Discussions: Sulfonic nano polymers through formulation methods can be enhanced for therapeutic application of drug resistant Neisseria Gonorrhoeae.
