Abstract Text: The results of a pilot study of immune-related biomarkers among patients (N=235) with personality disorders in association with suicidal behavior will be presented. The study has examined the associations of a broad range of biomarkers reflecting neuroinflammation, compromised blood brain barrier function and altered cytokine and chemokine signaling with self-harm and suicidal behavior among individuals with personality disorders. Biomarkers include plasma protein levels of several mediators of neuroinflammation, chemokines, blood-brain barrier biomarkers, CAMS, IL-18 system, and defensins. Levels of the neuroimmune factors are compared between patients with personality disorders who have and those we do not report a self-harm/suicidal behavior. Comparison include patients with personality disorder and healthy controls that are gender and age-matched. Samples are obtained from a large database of healthy controls and psychiatric population with personality disorders as part of a Norwegian network of personality disorder.
