W110 - Immune Therapy of Sickle Cell Disease and Its Prophylaxis

Abstract Text: Problem: Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide distribution. Alternate complement system is hyper activated contributing to acute sickle cell related vaso-occlusive crises. (Lombardi E. et al "Factor H interferes with the adhesion
of sickle red cells to vascular endothelium: a novel disease-modulating molecule in Haematologica 2019 Volume 104(5):919-928)

Method: Sulfonic nanopolymers are developed as inhibitor of Factor D to reduce host inflammatory reaction to hyper activated alternate complement system
Discussions: Sulfonic nanopolymers in appropriae formulation strategies may prevent sickle cell vaso-occlusive crisis and may be used both for immune therapy and prophylaxis.