Abstract Text: Latin population has been underrepresented in IBD GWAS. We investigate the association of IBD risk variants reported in previous GWAS studies with clinical outcomes in Chilean patients. Methods. Chilean individuals with IBD (145 UC and 47 CD) were genotyped using Illumina GSA Arrays. From IBD GWAS (Jostin et al. and Liu et al.), we selected gene variants and looked for them in our Chilean IBD group. Then, we built a Chilean dataset. Using this dataset, we performed a Spearman correlation matrix to correlate clinical outcomes with IBD variants. Further, we built regression models to predict the clinical outcomes using the variants obtained from the correlation matrix (p < 0.05). Then, we selected the best models using significance testing (P values) or likelihood-based information criterion, such as the Akaike Information Criterion (AIC) and plotted the models using a Receiver Operating Characteristic Curve (ROC). Finally, to evaluate the association among variants in each model, we perform a Gene Ontology biological process enrichment analysis using PANTHER (Fisher, FDR). Results. The best predictive regression models (more than 80% AUC >80 ) for the clinical outcomes were surgery, clinical/endoscopy remission for more than five years, and naïve anti-TNF. Association with genes related to genetic variants was observed significantly (p < 0.05) in the enrichment analysis for the model Clinical/endoscopy remission of more than five years (rs6837335,rs11742570,rs6871626,rs38904,rs7133914,rs7134599,rs1708507, and rs6142618). Conclusion. Candidates' genes related to clinical outcomes in our Chilean IBD cohort were related to epithelial, innate, and adaptative immune responses and host-microbial interactions.
