W145 - Development of Knowledge Tree Based on Recent Advances in Genomics and Fundamentals of Immunology

Abstract Text: Problem: Self--Non--Self based models of cellular or adaptive immunity is used in Covid-19 both as vaccines and monoclonal antibody therapy. Both, are experiencing immune evasion, immune resistance due to SARS-CoV2 variants offering continuing risk of Covid-19 infection and future explosion of pandemics.

Method: We identify "Alternate Complement System" as a key Self--Non--Self Fluid mediator that plays a prominent role in both fluid and cellular immunity. We identify in Pub Med Central 15221scientific articles as of 01/15/2023. They are related to "Alternate Complement system" Under "Factor H Term" https://www.ncbi.nlm.nih.gov/pmc/?term=Factor+H".
Above articles are periodically examined and categorized to develop "Knowledge Tree" of medicine. This is described as subdivision of Tree such as
A. Trunk represent the basic foundation of "Recent Advances in Genomics and Fundamentals of Immunology" that is narrowed down to Factor H and Factor D.
B. Branches: Represent different medical specialities such as Neurology, ophthalmology, oncology, Endocrinology, Pandemics, Transplantation, Hematology and Obstetrics etc.
C. Leaves represent different major life threatening diseases in above medical specialties.
Result: We developed sulfonic nanopolymers for balanced inhibition of Factor H and Factor D. Novel formulation methods can be developed to target different major life threatening diseases in different medical specialities. Enhanced human safety, reduced risk of adverse effects, reduce risk of immune evasion and immune resistance are the potential future benefits with prospect of herd immunity at global level.