Professor
University of Calgary
Calgary, Alberta, Canada
I am Professor in the Department of Microbiology, Immunology and Infectious Diseases at the Cumming School of Medicine at the University of Calgary, Canada, and Group Leader at the Institut D'Investigacions Biomèdiques August Pi i Sunyer in Barcelona, Spain. I am an elected Fellow of the Royal Society of Canada, elected member of the Royal Academy of Medicine of Catalonia, Spain, and Founder of Parvus Therapeutics Inc.
The focus of most of my scientific work has been to try to understand the immunogenetics and immunopathogenesis of autoimmune disorders, with a particular emphasis on type 1 diabetes, to try to find targets for therapeutic intervention. Early efforts centered on the relationship between genetic susceptibility and resistance to autoimmunity and T-cell tolerance. This work led to the serendipitous discovery of a new therapeutic approach for the treatment of chronic inflammatory disorders based on nanomedicine. This therapeutic approach triggers the formation of extensive antigen- and disease-specific networks of regulatory T and B-cells that efficiently suppress the progression of several different autoimmune disorders without compromising systemic immunity. Current efforts focus on dissecting the mechanisms that sustain and regulate these regulatory cellular networks, the developmental origin(s) of their cellular components and the molecules that control cell-to-cell communication within the networks. My goal is to bring this technology to the clinic.
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Re-programing Autoreactivity to Suppress Autoimmunity
Wednesday, June 21, 2023
2:20 PM - 2:45 PM Â
