Professor
University of California, San Francisco
San Francisco, California, United States
Matthew Krummel, PhD is the Chair of the UCSF ImmunoX Initiative (https://immunox.ucsf.edu/)
and holds the Robert E. Smith Endowed Chair in Pathology. His lab (http://krummellab.com/)
specializes in using real-time imaging to launch and test hypotheses related to how the immune
system processes information and makes decisions. Key recent discoveries have included
determining features of T cell membrane topology that govern how they efficiently survey for
antigens as well as the discovery of archetypal collections of immune systems in cancer,
notably those involving networks of cells-built-around stimulatory dendritic cells and other
myeloid cells and their cooperativity with adaptive immunity . His work spans scales from
membrane organization, to cell biology, to entire immune systems. He received his PhD at the
Berkeley and did postdoctoral studies at WEHI and Stanford.
Dr. Krummel drives collaborative science: he founded a microscopy ‘collaboratory’
which unites ‘shared’ technical personnel and he developed a novel industry consortium-funded
project (http://immunoprofiler.org/) uniting studies of over 15 cancer indications to
understand the biology of individual patients. Together with other UCSF faculty, he founded the
ImmunoX initiative, a radical collaboration platform focused on methods and data sharing as a
means to accelerate discovery and cures. This included the vision and resourcing to establish
CoProjects and CoLabs at UCSF. These initiatives also emphasizes public outreach and
interaction as a means to disseminate the value of science. Dr. Krummel’s work has led to
multiple clinical advances including co-discovering anti-CTLA-4 ‘checkpoint blockade’ drugs
(over 100,000 patients treated) and-new next-generation therapies through-Pionyr and Foundery.
Disclosure information not submitted.
Discovering and Understanding Immune Archetypes in Cancer
Wednesday, June 21, 2023
1:40 PM - 2:05 PM
