E.F. Brigham Professor of Medicine
Brigham and Women's Hospital, Harvard Medical School
Newton, Massachusetts, United States
Michael Brenner is the E.F. Brigham Professor of Medicine at Harvard Medical School and Director of the Human Immunology Center at BWH. He is a member of the National Academy of Sciences, USA, Fellow of the American Academy of Microbiology and the Fellow of the American Association for the Advancement of Science. He received the Lee C. Howley Prize for Research in Arthritis (Arthritis Foundation), the Distinguished Basic Investigator Award (ACR) and the Carol-Nachman Prize in Rheumatology (International).
Brenner’s translational research accomplishments in RA include defining: 1) mechanisms of fibroblasts mediated joint inflammation and damage, 2) mechanisms of activation, 3) role of cadherins and NOTCH signaling in fibroblast mediated pathology. He discovered new lymphocyte populations including 4) T peripheral helper T (Tph) cells that that drive B cell differentiation and antibody production and 5) Granzyme K CD8 T cells that drive complement activation.
Brenner’s basic biology accomplishments include discovery of 1) gamma delta T cells, 2) the system of lipid antigen presentation mediated by CD1 molecules that bind and present lipid antigens for recognition by T cell receptors, 3) roles of CD1-restricted T cells in host defence and adipose tissue inflammation, metabolism and thermogenesis, 4) role of the alphaEbeta7 integrin in mucosal leukocyte trafficking, 5) role of the molecular chaperone role of IP90 (calnexin) in TCR and MHC protein complex assembly, and 6) role of small GTPase Arl proteins in endocytic trafficking and antigen presentation.
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CD8 T cell derived granzyme K drives a new pathway of complement activation in inflamed tissues
Friday, June 23, 2023
8:00 AM - 8:30 AM
